乳腺癌等级的变化从活检到切除术后的手术或初级化疗
Ádám Ferenczi1, Gábor Cserni1,2
1Department of Pathology, University of Szeged, Szeged, Hungary.
Pathologica
|March 14, 2024
概括
经过核心针活检 (CNB) 和外科切除 (EXC) 评估的乳腺癌组织学等级 (G) 显示出不同的一致率,特别是在接受初级化疗 (PST) 患者的线粒细胞计数 (M) 和等级 (G) 中.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 手术瘤学手术瘤学
背景情况:
- 准确的乳腺癌组织学分类对于治疗决策和预后至关重要.
- 核心针活检 (CNB) 经常用于初步诊断,但它们与最终切割样本 (EXC) 的一致性需要评估.
- 新辅助化疗对组织学等级评估的影响需要进一步了解.
研究的目的:
- 为了比较CNB和EXC标本之间的组织学等级 (G) 和其组成部分 (管体形成 - T,核形 - P,线粒细胞计数 - M).
- 为了评估这些比较,在接受初级手术 (CHIR) 与初级化疗 (PST) 治疗的患者中.
主要方法:
- 分析了匹配的乳腺癌活检 (CNB) 和切除样本 (EXC) 的对.
- 组织学分级使用诺丁汉分级系统进行.
- 对T,P,M和G的一致率计算了CHIR和PST组.
主要成果:
- 对T,P,M和G的一致率在CHIR和PST组之间有所不同.
- 对于线粒细胞计数 (M) 和整体等级 (G) 观察到一致性的显著差异,在PST组一致性较低.
- 在PST组中,核针活检显示,与切除样本相比,核针活检倾向于低估线粒细胞计数和整体等级,这可能是由于化疗的影响.
结论:
- 化疗显著影响了线粒细胞计数和组织学等级的评估,导致活检和切除样本之间的一致性较低.
- 在化疗后的切除样本中观察到的线粒活性和等级的减少,需要进一步调查预后影响.
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