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停止使用酸受抑郁症状的影响:回顾性分析
Frederik Krefting1, Stefanie Hölsken2, Manfred Schedlowski3
1Department of Dermatology, Venereology and Allergology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Frederik.krefting@uk-essen.de.
Acta dermato-venereologica
|March 14, 2024
概括
患有抑郁症的牛皮患者更有可能因副作用而停止使用酸 (FAE) 治疗. 这表明需要在这些患者中管理nocebo效应,以更好地遵守治疗.
科学领域:
- 皮肤病学 皮肤病学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 酸 (FAE) 是适度至重症牛皮的常见治疗方法.
- 用FAE治疗的成功往往受到不良事件 (AE) 或反应不佳的限制.
- 牛皮患者经常出现抑郁症状,可能会影响治疗结果.
研究的目的:
- 为了调查与并发性抑郁症状相关的牛皮患者是否更容易停止FAE治疗.
- 为了确定抑郁症是否会影响因副作用或治疗反应不足而停止治疗.
主要方法:
- 在2017-2022年期间,对95名接受FAE治疗的牛皮患者进行了回顾性分析.
- 评估牛皮的严重程度,抑郁症状,副作用,并在前52周内停止治疗.
- 统计分析以将抑郁症症状与停止治疗相关联.
主要成果:
- 患有抑郁症状的牛皮患者 (42.11%) 由于患者报告的AEs,更有可能停止FAE治疗.
- 报告的AE总数与抑郁症没有相关性.
- 研究结果支持这样一个假设:抑郁症会增加对AEs的敏感性,导致更快地停止治疗.
结论:
- 牛皮患者的抑郁症状与由于感知到AE的FAE治疗中止的可能性更高有关.
- 通过有针对性的沟通策略,最大限度地降低nocebo效应对于改善抑郁症患者的FAE治疗坚持至关重要.
- 对影响牛皮治疗结果的心理因素进行进一步研究是有必要的.
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