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Updated: Jul 1, 2025

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
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在ATTR (105-115) 组装中的β丰富寡合体的结构和动力学

Liqun Liang1, Yuqi Zhang1, Yanyan Zhu1

  • 1College of Mathematics and Physics, Shanghai University of Electric Power, Shanghai 200090, China.

ACS chemical neuroscience
|March 14, 2024
PubMed
概括

错误折叠的TTR聚合成有毒的粉样蛋白寡合体. 分子动力学模拟显示,水性相互作用驱动β丰富的寡合体的形成,可能通过β-桶中间体,为神经退行性疾病机制提供了洞察力.

关键词:
在ATR (105-115) 中.分子动力学模拟模拟蛋白质蛋白质是蛋白质蛋白质的组成部分.蛋白质-蛋白质相互作用在β-barrel中使用.

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