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Updated: Jul 1, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

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能够点击的Phenanthriplatin衍生物作为研究Pt (II) 诱导的核应激的工具

Paul D O'Dowd1,2, Andres S Guerrero3, Katelyn R Alley3

  • 1Department of Chemistry, Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland.

ACS chemical biology
|March 14, 2024
PubMed
概括

研究人员开发了新的点击复合物来研究抗癌药物如何引起核应激. 这些化合物模仿细胞反应,有助于发现药物点和设计新的治疗方法.

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Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules

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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

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相关概念视频

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)01:15

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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