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Updated: Jul 1, 2025

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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C9orf72聚PR直接与各种核运输部件结合

Hamidreza Jafarinia1, Erik van der Giessen1, Patrick R Onck1

  • 1Zernike Institute for Advanced Materials, University of Groningen, Groningen, Netherlands.

eLife
|March 14, 2024
PubMed
概括

富含氨酸的二聚重复蛋白 (R-DPR) 通过与关键运输蛋白结合,破坏C9orf72-ALS中的核运输. 这种分子相互作用解释了核细胞质运输 (NCT) 和C9orf72毒性的潜在缺陷.

关键词:
在ALS/FTD中,C9orf7272 是一个很好的方法.在进口/出口中分子动力学分子动力学神经科学 神经科学没有,没有,没有.核孔复合体是核孔复合体.核细胞质体运输是核细胞质体运输.生物系统的物理生活系统的物理.

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