饮食,微生物群和后生物在结肠直肠癌中的关键作用
Rüya Kuru-Yaşar1, Özlem Üstün-Aytekin2
1Department of Nutrition and Dietetics, Hamidiye Faculty of Health Sciences, University of Health Sciences, 34668, Istanbul, Türkiye.
Current nutrition reports
|March 14, 2024
概括
来自有益的肠道细菌的后生物,通过抑制瘤生长和调节免疫系统,在预防和治疗结直肠癌方面表现有前途. 需要进一步的研究来证实它们的有效性和安全性.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因,发病率越来越高.
- 肠道微生物群失调与CRC的发展有关.
- 益生菌在CRC治疗中存在局限性,原因是安全性和耐药性问题,重点转移到后生菌.
研究的目的:
- 综合审查有关饮食,微生物群和后生物质对结直肠癌的影响的文献.
- 评估后生物在CRC预防和治疗中的潜力.
主要方法:
- 关于调查饮食,肠道微生物群和后生菌与结直肠癌相关的研究的文献综述.
- 分析后生物质影响CRC进展的机制.
主要成果:
- 肠道微生物群通过瘤代谢产物和瘤抑制代谢产物影响CRC.
- 后生菌在诱导亡,抑制扩散和入侵,调节免疫力和增强CRC中的化疗疗效率方面显示出潜力.
- 一些后生菌可能是无效的或在某些患者群体中构成安全风险.
结论:
- 后生物药物代表着对结直肠癌的有前途的治疗策略.
- 进一步的大规模,随机,双盲临床试验对于验证后生菌在慢性肺癌管理中的有效性和安全性至关重要.
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