杏仁体体积与青少年的ADHD风险和并发症之外的严重程度有关:脑图参考标准的临床测试
Ádám Nárai1,2, Petra Hermann1, Alexandra Rádosi3,4
1Brain Imaging Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.
Research on child and adolescent psychopathology
|March 14, 2024
概括
脑图显示,青少年的杏仁体体积较小与注意力缺陷/多动障碍 (ADHD) 的风险和严重程度较高有关. 这一发现有助于理解ADHD病因和个体预测.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 精神病学是一个精神病学.
背景情况:
- 了解大脑结构的非典型性对于ADHD病因学至关重要.
- 准确的评估需要规范性大脑参考标准.
- 脑图为评估个体大脑变异提供了一种新的方法.
研究的目的:
- 在青少年中应用脑图,以评估与ADHD风险相关的异常大脑体积.
- 调查皮下和总大脑体积与ADHD症状严重程度之间的关联.
- 在分析中考虑焦虑,抑郁和对立挑障碍 (ODD) 等并发症.
主要方法:
- 在140名青少年 (38%女性) 的样本中,利用脑图进行规范性比较.
- 检查了大脑体积和ADHD风险状况和症状严重程度之间的关联.
- 对自我评价的焦虑和抑郁症,父母评价的ODD和运动工件进行了控制.
主要成果:
- 较小的双边杏仁体体积与ADHD风险状况显著相关,独立于并发症和运动.
- 杏仁体体积减少与注意力不集中和过度活跃/冲动症状相关,即使考虑到大多数并发症和运动.
- 对立的挑性障碍症状被认为是与杏仁体体积相关的潜在混因素.
结论:
- 个体桃体体积差异对估计ADHD风险和严重程度有显著的贡献.
- 杏仁体的参与与ADHD中非典型的强化敏感性理论一致.
- 脑图参考标准对于ADHD中临床相关的神经成像研究是有效的.
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