星球细胞通过影响CA1→ACC投射到engrams的招募来控制近期和远程记忆强度
Ron Refaeli1, Tirzah Kreisel1, Tamar Ravins Yaish2
1Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Cell reports
|March 14, 2024
概括
在海马体中调节天体细胞通路 (CA1) 影响记忆回忆. Gq激活增强了最近的记忆,而Gi激活通过改变CA1神经元投射来损害远程记忆.
科学领域:
- 神经科学是一个神经科学.
- 细胞和分子神经科学
背景情况:
- 记忆的成熟涉及随着时间的推移发生的engram变化,招募特定的神经元群体,如向前带带皮层 (CA1→ACC) 投射的CA1神经元.
- 在CA1星球细胞中,G蛋白结合受体 (GPCR) 路径对最近和远程记忆的回忆有不同的影响,具有复杂的调节作用.
研究的目的:
- 研究CA1天体细胞中GPCR路径修改对近期和远程记忆回忆的看似矛盾的影响.
- 阐明CA1→ACC投影细胞在经过天体细胞路径操纵后的记忆回忆中的作用.
主要方法:
- 在记忆获取过程中操纵CA1天体细胞中的Gq和Gi通路.
- 在近期和远程回忆过程中标记c-Fos-阳性瘤细胞和CA1→ACC细胞.
- 将行为记忆回忆数据与神经元招募分析结合起来.
主要成果:
- 星球细胞中的Gq通路激活增强了最近的回忆力,并导致CA1→ACC细胞更早地被招募到engram中.
- 星细胞中的Gi通路激活损害了远程回忆,在远程记忆检索过程中缺乏CA1→ACC细胞招募.
- Gq和Gi通路对CA1→ACC投射细胞参与的不同影响与记忆回忆结果相关.
结论:
- 星细胞GPCR通路通过影响CA1→ACC投影神经元的招募来严重调节记忆回忆.
- 这些发现支持一个工作模型,其中Gq和Gi路径通过一个涉及CA1→ACC投影的共同机制差异调节记忆.
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