在美国成年人中,社会脆弱性与Streptococcus pneumoniae抗菌素耐药性之间的关联
Salini Mohanty1, Gang Ye2, Charles Sheets2
1Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, USA.
概括
社会脆弱性,特别是社会经济地位,与较高的新型肺炎菌株抗菌素耐药性 (AMR) 率有关. 在美国,家庭特征也显示出与AMR风险的关联.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 抗菌素耐药性 (AMR) 不成比例地影响社会脆弱地区的个体.
- 这项研究调查了社会脆弱性指数 (SVI) 与肺炎链球菌 (SP) AMR之间的联系.
研究的目的:
- 评估SVI和SP在美国抗菌素耐药性 (AMR) 之间的关联.
- 确定有助于SPAM风险的特定SVI主题.
主要方法:
- 在177个美国医疗机构 (2011-2022) 分析了来自成年患者 (≥18岁) 的8008个独特的SP分离物.
- 如果SP隔离物对关键抗生素类别不敏感,则被归类为AMR.
- 用于评估SP AMR和SVI分数 (整体和主题) 之间的关联的概括估计方程.
主要成果:
- 总体上,SP的AMR比例为49.9%.
- 更高的社会经济地位 (SES) SVI分数与增加的SP AMR风险 (1.28%的增长).
- 家庭特征SVI得分也显示了与SP AMR风险的积极关联 (每分数增加0.81%).
结论:
- 社会经济地位和家庭特征是与SP AMR相关的关键SVI主题.
- 这些发现强调了社会决定因素在抗菌素耐药性模式中的作用.
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