自杀,刺激剂和选择性血清素再吸收抑制剂:一个回顾性图表审查
Reena Thomas1, Austin Sellers2,3,4, Jamie L Fierstein3,5
1Department of Child and Adolescent Psychiatry, RĀZ MINDS, Tampa, Florida, USA.
Journal of child and adolescent psychopharmacology
|March 14, 2024
概括
选择性血清素再吸收抑制剂 (SSRI) 与兴奋剂相结合并没有显著增加年轻人的自杀风险. 在这个人群中,抑郁症诊断是自杀思想和行为 (STB) 的更强有力的预测因素.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 药理学 药理学是指药理学的学科.
- 心理健康研究 心理健康研究
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 与年轻人的自杀风险增加有关.
- 对于SSRI和兴奋剂对儿科患者自杀风险的综合影响尚不清楚.
研究的目的:
- 调查SSRI和兴奋剂联合使用与儿童和青少年的自杀思想和行为 (STB) 之间的联系.
- 为了确定其他因素,如抑郁症,是否会影响这种关系.
主要方法:
- 在儿童精神病诊所进行的回顾性队列研究 (2017-2020年).
- 包括349名年龄在6至21岁的患者,他们服用了处方兴奋剂或兴奋剂加上SSRI.
- 后勤回归分析了药物和STB之间的关联,并对共变量进行调整.
主要成果:
- 在研究队列中,STB的患病率为5.7%.
- 未经调整的分析显示,SSRI和兴奋剂联合使用时,性病风险更高.
- 在根据年龄,性别,焦虑和抑郁症进行调整后,联合药物和性病之间的关联减弱了 (OR: 1.3).
- 抑郁症的诊断与STB增加显著相关 (OR:3.6).
结论:
- 结合SSRI和兴奋剂的联合治疗没有显示出显著的独立关联与增加的STB在年轻人当调整为关键因素.
- 在这组患者中,抑郁症成为性病的重要危险因素.
- 需要进一步的前性研究来澄清组合药物治疗与儿科患者自杀风险之间的关系.
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