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作为膀疼痛综合征的生物标志物,泌尿神经素-1-酸盐

Erica Eggers¹, Tess Crouss¹, Lioudmila Lipetskaia¹

¹From the Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Cooper University Healthcare.

Urogynecology (Philadelphia, Pa.)

|March 14, 2024

概括

在膀疼痛综合征 (BPS) 患者中,与对照人群相比,尿液中的斯芬戈辛-1-酸盐 (S1P) 水平最初较高. 然而,当正常化为肌素时,这种差异消失了,这表明S1P可能不是可靠的BPS生物标志物.

科学领域:

生物化学和分子生物学
泌尿病学和脏病学
炎症和免疫学炎症和免疫学

背景情况:

氨酸-1-酸盐 (S1P) 是一种生物活性脂质调解剂,涉及炎症过程和光滑肌功能,包括膀收缩.
膀疼痛综合征 (BPS) 是一种慢性疾病,其特点是膀不适和疼痛,其潜在机制通常不清楚.
研究BPS的新生物标志物对于改善诊断和管理至关重要.

研究的目的:

为了比较BPS和健康对照的成年女性之间的尿液S1P度.
评估尿液S1P水平与BPS疾病严重程度和持续时间之间的相关性.
确定尿路S1P作为BPS的诊断或预后生物标志物的潜力.

主要方法:

采用了病例控制试点研究设计,招募了25名患有BPS的成年女性和25名年龄相匹配的对照.
尿中的S1P和肌氨酸度使用已知的方法量化.
标准化问卷 (O'Leary-Sant) 评估了BPS症状严重程度,以及症状持续时间和治疗史数据. 统计分析包括曼-惠特尼U测试和斯皮尔曼相关性.

主要成果:

在BPS组 (1,225 ng/dL) 和对照组 (2,183 ng/dL) (P < 0.0001) 之间观察到尿中S1P度中位数的统计学上显著差异.
当S1P度正常化为尿氨酸时 (P = 0.58) 这一显著差异没有持续.
尿中S1P水平 (正常化或非正常化) 和BPS症状严重程度或症状持续时间 (P>0.05对所有患者) 之间没有发现显著的相关性.

结论:

这项研究成功量化了人类尿路S1P,证明了BPS患者和对照人群之间的初始差异.
肌素正常化后缺乏持续差异表明,尿液S1P可能不能作为BPS的可靠生物标志物.
需要进一步的研究来探索S1P在BPS病原发生中的潜在作用,并验证在更大的队列中发现的结果.

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