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一碳代谢作为胎盘DNA甲基化的一个潜在途径 - - 一项系统性审查

Marjolein M van Vliet^1,2, Sam Schoenmakers¹, Joost Gribnau²

¹Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands.

|March 14, 2024

概括

父母暴露对胎儿发育的影响通过表观遗传修饰,如DNA甲基化. 微量营养素支持这一过程,但它们与胎盘DNA甲基化直接关联需要进一步研究终身健康影响.

科学领域:

表观遗传学和发育生物学
营养生物化学营养生物化学
基因组学就是基因组学.

背景情况:

表观遗传修饰,特别是DNA甲基化,对于调解父母暴露对胎儿发育和长期健康的影响至关重要.
叶酸,胆和维生素B12等微量营养素对于单碳代谢至关重要,这直接影响了DNA甲基化过程.

研究的目的:

系统地审查关于一碳代谢和人类胎盘DNA甲基化之间的关联的现有文献.
确定胎盘DNA甲基化中的潜在目标,以改善产科护理.

主要方法:

对22项研究的系统审查,包括临床 (n=15) 和体外 (n=3) 研究.
分析按研究方法分类:全球DNA甲基化 (n=9),全基因组分析 (n=4),基因特异性分析 (n=14).
包括具有最低ErasmusAGE质量评分为5/10的临床研究.

主要成果:

一个碳部分通常与全球DNA甲基化没有关联,对胆有一些相互矛盾的结果.
全基因组分析揭示了与S-adenosylmethionine (SAM),S-adenosylhomocysteine (SAH) 或饮食模式相关的有限的差异甲基化位点.
基因特异性研究表明,单碳部分和参与生长的基因 (例如LEP,NR3C1,CRH,PlgF) 之间存在特定位置的关系,尽管研究之间的重叠很小.

结论:

单碳代谢对胎盘DNA甲基化的直接影响是复杂的,通常是基因或区域特定的.
建议进行进一步的研究,以阐明优化一碳代谢在DNA甲基化中的精确作用及其对终身健康的影响.
由单碳部分影响的胎盘DNA甲基化为新的产科护理策略提供了潜在的途径.

关键词:

多哈德 (Dohad) 是一个城市.表观遗传学是指表观遗传学.人类人类人类人类人类人类人类营养营养营养营养

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