患有血液性恶性瘤,发烧性中性质和败血性休克的患者的死亡率
Beda Islas-Muñoz1, Patricia Volkow-Fernández1, Jorge Silva-Zamora1
1Infectious Diseases Department, Instituto Nacional de Cancerología (INCan), Alcaldía Tlalpan, 14000 Mexico City.
Journal of infection in developing countries
|March 14, 2024
概括
患有血液性恶性瘤的患者严重的中性质衰竭显著增加了感染性休克 (SS) 和死亡的风险. 长时间的中性质衰竭和记录的感染是发展SS和死亡的关键风险因素.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 患有血性恶性瘤 (HM) 的患者容易发生严重的中性衰竭.
- 严重的中性质缺血增加了危及生命的感染的风险,包括败血症休克 (SS).
- 了解这一群体中SS的风险因素对于改善结果至关重要.
研究的目的:
- 评估与感染性休克 (SS) 发展相关的风险因素.
- 评估患有HM和发烧性中性质疏松症的患者的死亡率,这些患者患有SS.
- 在这个患者队列中确定SS和30天死亡率的预测因素.
主要方法:
- 在一年内对患有HM,发烧和严重中性质减退的患者进行了回顾性研究.
- 收录标准:癌症第三级护理中心的入院,发烧和严重的中性质减退.
- 收集有关感染类型,微生物培养和患者结局的数据.
主要成果:
- 23.2%的患者发生了SS. 在SS患者中,记录的感染,特别是肺炎,更为频繁.
- 阳性培养和格拉姆阴性细菌 (大肠杆菌,Klebsiella spp.) 的比率更高. 在SS患者中观察到.
- 斯斯的危险因素包括长期的中性质减退,记录的感染部位和高度肌肉抑制的化疗. 死亡风险因素包括年龄较大,长期中性质减退和SS.
结论:
- 严重和长期的中性质疏松症与SS的发展和30天死亡率的增加有显著关联.
- 在HM患者中早期识别和管理SS至关重要.
- 应考虑重症监护病房 (ICU) 管理,对于预计长期存活的重症病患者.
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