在人工循环中使用微化阴道孕激素作为囊或囊来支持状阶段:有什么区别吗?
Elena Labarta1, Cristina Rodríguez-Varela2, Maria Salvaleda-Mateu2
1IVI Foundation, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.; Human Reproduction Department, IVI RMA Valencia, Valencia, Spain..
Reproductive biomedicine online
|March 14, 2024
概括
在激素替代疗法-胚胎移植 (HRT-ET) 周期中,用于黄质阶段支持的微型化阴道孕激素 (MVP) 囊导致血清孕激素水平高于囊. 这减少了需要额外的孕激素救援治疗的需要.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 在激素替代治疗-胚胎移植 (HRT-ET) 周期中,质阶段支持 (LPS) 是至关重要的.
- 微型化阴道孕激素 (MVP) 是常用于LPS的药物,以囊和囊形式提供.
- 在胚胎移植之日,低于最佳的血清孕激素水平可能会影响结果.
研究的目的:
- 在HRT-ET周期中比较MVP囊与LPS囊的疗效.
- 为了确定MVP配方是否会影响胚胎移植当天的血清孕激素度.
- 根据MVP配方,评估患有低于最佳水平的孕激素水平 (<8.8 ng/ml) 的患者比例.
主要方法:
- 追溯性,匹配的队列,单中心研究.
- 在2665个HRT-ET周期中比较了MVP囊 (Cyclogest) 与囊 (Utrogestan,Progeffik).
- 在胚胎移植日测量血清孕激素;如果<8.8 ng/ml,则给予救援孕激素.
主要成果:
- 平均血清孕激素水平与MVP囊 (14.5 ± 5.1 ng/ml) 比囊 (13.0 ± 4.8 ng/ml) 显著更高.
- 与囊 (17.9%) 相比,使用MVP囊的患者数量较少,其孕激素水平低于最佳水平 (10.3%).
- 两组之间没有观察到怀孕结果的显著差异.
结论:
- 与囊相比,MVP囊导致胚胎移植当天血清孕激素低于最佳水平的患者显著减少.
- 对LPS使用MVP囊几乎将救援孕激素治疗的需求减少了一半.
- 在HRT-ET周期期间,MVP配方可能会影响孕激素的生物可用性.
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