加快抗生素获取和管理:保护公共健康的新模式
Jennifer Cohn1, Marc Mendelson2, Souha S Kanj3
1Global Antibiotic Research and Development Partnership, Geneva, Switzerland.
The Lancet. Infectious diseases
|March 14, 2024
概括
在低收入国家,抗生素耐药性是一个日益严重的问题,在这些国家,获得负担得起的抗生素是有限的. 建议采用适应环境的管理新模式,以确保可持续地获得必需药物.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 药物经济学 药物经济学
背景情况:
- 细菌抗菌药物耐药性是一个重大挑战,特别是在低收入和中等收入国家 (LMICs).
- 在为患者提供有效和负担得起的抗菌药物治疗方面,LMICs面临着巨大的障碍.
- 传统的抗微生物药物管理计划,通常是资源密集的,专注于成本控制,由于财务,卫生系统和人力资源的限制,很难在LMIC中实施.
研究的目的:
- 建议对LMICs的抗菌药物管理进行范式转变,从资源密集型模型转向专注于可持续获取.
- 引入适应环境的管理模式,确保适当使用抗生素,同时最大限度地利用稀缺的资源.
- 确定实用干预措施,以改善资源有限的环境中的抗生素获取和管理.
主要方法:
- 审查在LMICs中抗菌素耐药性管理方面的挑战.
- 适应传统的抗微生物药物管理原则,以资源有限的环境.
- 探索其他疾病领域的干预措施,如结核病,用于抗生素管理.
主要成果:
- 传统的管理模式在LMIC中往往是不可持续的.
- 可持续的访问模式需要适应环境的管理,重点关注可负担性和适当的使用.
- 干预措施,如任务转移和枢纽式模型,可以提高抗生素的获取和管理.
结论:
- 转向可持续的获取和适应环境的管理对LMICs来说至关重要,以打击抗菌素耐药性.
- 任务转移和集线模型为优化资源有限的环境中的抗生素使用和获取提供了可行的策略.
- 在LMIC中,有效的抗微生物药物管理必须优先考虑负担能力和适当的处方,以确保患者的结果并保持药物的有效性.
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