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由ROS驱动的超分子纳米颗粒显示了化学/化学动力学联合治疗癌症治疗的高效药物输送

Huikun Chen¹, Chengyuan Xing², Hanqi Lei³

¹Department of Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China; Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.

Journal of controlled release : official journal of the Controlled Release Society

|March 14, 2024

概括

这项研究开发了新的纳米粒子,用于增强化疗. 这些纳米颗粒有效地向瘤,释放帕克利塔塞尔 (PTX) 作为对活性氧物种 (ROS) 的反应,并提高治疗效率.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

基于药物的超分子自组装系统可以提高药物的生物可用性,但在递送效率和响应性释放方面面临挑战.
帕克利塔塞尔 (PTX) 是一种强效的化疗剂,由于生物可用性差和全身副作用,有效性有限.

研究的目的:

开发一种新型的超分子纳米粒子 (NP) 系统,用于高效的帕克利塔塞尔 (PTX) 输送.
为了设计NP,以响应瘤微环境的活性氧物种 (ROS),释放PTX.
调查这些NP的协同化疗潜力.

主要方法:

合成的per-6-thio-β-cyclodextrin (CD) 通过ROS敏感的 thioketal (TK) 连接 (CDTP) 与PTX结合.
通过通过宿主-客人相互作用结合PEGylated ferrocene (Fc) 来构建超分子NP (CDTP@Fc-PEG).
评估了NP吸收,ROS生成,谷氨 (GSH) 消耗和细胞毒性在体外和体内.

主要成果:

CDTP@Fc-PEG NPs证明了有效的瘤细胞吸收和细胞内ROS升高.
通过降低GSH水平,NP破坏了癌细胞中的氧化还原平衡.
观察到有效的瘤积累和增强的细胞毒性,对健康器官的毒性最小.

结论:

CDTP@Fc-PEG NPs代表了对PTX的一个有前途的超分子纳米输送平台.
该系统可以通过ROS响应释放实现高药载荷和协同化疗.
这种方法提供了一种战略,可以克服传统化疗的局限性.

关键词:

破坏了氧化还原平衡.芬顿反应是芬顿反应的一个反应.提供纳米药物的纳米药物.一个药物产品.超分子自我组装的过程瘤治疗疗法瘤治疗

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