[翻译文章] 在实验室从PMMA骨水泥中化局部麻醉剂
M Monfort-Mira1, M Jornet-Gibert1, C Yela-Verdú2
1Departamento de Cirugía Ortopédica y Traumatología, Hospital Clínic, Barcelona, Spain.
Revista espanola de cirugia ortopedica y traumatologia
|March 14, 2024
概括
利多卡因和布皮瓦卡因等局部麻醉剂可以从聚甲基甲酸盐 (PMMA) 骨中释放出来. 这项研究描述了它们的化概况,以潜在地用于术后疼痛管理.
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
- 生物材料科学 生物材料科学
背景情况:
- 在全膝关节整形术后有效的疼痛管理仍然是一个挑战,目前没有黄金标准.
- 使用药物输送系统,但缺少理想的术后解决方案.
- 自20世纪70年代以来,聚甲基甲酸盐 (PMMA) 骨头水泥作为药物输送系统的使用历史已有.
研究的目的:
- 从PMMA骨水泥中描述利多卡因化物和布皮瓦卡因化物的化特征.
- 评估PMMA骨水泥作为全膝关节关节整形手术后治疗疼痛的局部麻醉剂储存的潜力.
主要方法:
- 准备了Palacos® R+G骨质水泥样本,装有利多卡因化或布皮瓦卡因化.
- 标本被浸入酸盐缓冲盐水 (PBS) 中,并在不同的时间点取样.
- 在PBS中的局部麻醉剂度使用液态染色学量化.
主要成果:
- 在72小时后,利多卡因化达到9.74%,在336小时后达到18.73%.
- 布皮瓦卡因的化在72小时后为2.71%,在336小时后为2.70%.
- 在72小时内化剂量接近临床麻醉阻塞中使用的剂量.
结论:
- 局部麻醉剂在实验室中证明了PMMA骨的化.
- PMMA骨水泥显示出作为局部药物输送系统用于术后疼痛控制的潜力.
- 进一步的研究可能会优化麻醉剂的化,以改善手术恢复.
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