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利用全基因组与血清25-基维生素D相互作用的元分析,以确定与肺功能相关的新型遗传位置

Jungkyun Seo¹, Nathan C Gaddis², Bonnie K Patchen³

¹Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States.

The American journal of clinical nutrition

|March 14, 2024

概括

较高的维生素D水平与更好的肺功能有关. 这项研究确定了与维生素D相互作用的新遗传变异,以影响肺功能,突出了肺健康中的基因环境相互作用.

科学领域:

遗传学是一个遗传学.
肺部病理学肺部病理学
营养科学营养科学

背景情况:

血清25-氧维生素D (25(OH) D) 度与肺功能有积极的相关性.
研究与25(OH) D的全基因组相互作用可能会揭示影响肺功能的新生物学途径.

研究的目的:

确定与肺功能相关的新型遗传变异,特别是第一秒内强制呼气体积 (FEV1) 和强制生命能力 (FVC).
探索基因变异和25(OH) D度之间的相互作用对肺功能的影响,考虑祖先和吸烟史.

主要方法:

全基因组关联研究 (GWAS) 的元分析对4个祖先背景的211,264名英国生物库参与者进行.
分析使用联合2自由度 (2df) 方法来考虑变体×25(OH) D相互作用,按吸烟史分层.
进行了途径丰富分析,以评估已识别的遗传变异的生物相关性.

主要成果:

通过GWAS元分析确定了30种与FEV1或FVC显著相关的新型遗传变异,这些变异占25...OH) D相互作用.
这些变异在与肺功能相关的途径中得到丰富,例如p38 MAPK途径.
五种变体显示出显著的25(OH) D相互作用,影响FEV1在从未和曾经吸烟者中,特定的变体显示出基于吸烟状态的差异性影响.

结论:

与肺功能相关的遗传关联被25(OH) D水平显著改变.
吸烟史进一步调节了这些变体×25(OH) D相互作用,强调了基因环境相互作用在确定肺功能中的作用.
这些发现扩大了对肺功能遗传结构的理解,以及维生素D和吸烟等环境因素的影响.

关键词:

英国生物银行基因与环境的相互作用.全基因组关联研究研究.肺功能肺功能肺功能维生素D是维生素D的重要组成部分.

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