冠状动脉微血管功能障碍患者的吸烟和呼吸系统疾病
Ophir Freund1, Aviel Shetrit2, Amir Bar-Shai3
1Institute of Pulmonary Medicine, Tel Aviv Sourasky Medical Center, and Tel Aviv University School of Medicine, Israel; Department of Internal Medicine B, Tel Aviv Sourasky Medical Center, and Tel Aviv University School of Medicine, Israel.
目前的吸烟和阻塞性睡眠呼吸暂停是冠状动脉微血管疾病 (CMD) 的关键风险因素. 在吸烟者中,更高的吸烟包年也强烈预测了CMD,强调了需要提高认识和干预的必要性.
科学领域:
- 心脏病学 心脏病学
- 呼吸系统医学 呼吸系统医学
- 血管生物学 血管生物学
背景情况:
- 冠状动脉微血管疾病 (CMD) 是普遍存在的,并与糟糕的结果有关.
- 众所周知,呼吸道因素会影响微血管功能,但它们与CMD的联系尚未得到充分研究.
- 关于呼吸系统变量与CMD之间的关联的证据有限.
研究的目的:
- 调查与呼吸系统相关的变量作为CMD的潜在风险因素.
- 为了评估吸烟,睡眠呼吸暂停,COPD和CMD之间的关联.
- 在接受侵入性冠状动脉微血管评估的患者中确定CMD的预测因子.
主要方法:
- 观察性,单中心研究设计.
- 包括连续接受侵袭性冠状动脉微血管功能评估的患者.
- 排除患有阻塞性冠状动脉疾病或缺少数据的患者.
- 单变量和多变量回归分析,以评估呼吸变量和CMD之间的关联.
主要成果:
- 在266名患者中,有155名患者 (58%) 呈现CMD.
- 当前吸烟 (AOR 2.5) 和阻塞性睡眠呼吸暂停 (AOR 5.7) 是CMD的独立预测因素.
- 在常吸烟者中,更高的吸烟包年独立预测CMD (AOR1.09).
- 慢性阻塞性肺病并不是一个重要的预测因素.
结论:
- 目前的吸烟和阻塞性睡眠呼吸暂停独立地与CMD相关.
- 增加吸烟包年是吸烟者中CMD的重要危险因素.
- 研究结果强调了在预防和治疗中识别呼吸道因素的重要性.
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