法属波利尼西亚的痛风流行:对来自Ma'i u'u流行病学调查数据的建模研究
Tristan Pascart1, Kaja A Wasik2, Cristian Preda3
1Service de Rhumatologie, Hôpital Saint-Philibert, Lille, France.
The Lancet. Global health
|March 14, 2024
概括
痛风影响了法属波利尼西亚近15%的成年人,高尿素血常见超过70%. 这项研究强调,迫切需要更好地获得尿酸降低疗法,以管理这种广泛的炎症性关节炎.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 痛风是全球炎症性关节炎的主要原因,太平洋地区的流行率很高.
- 法属波利尼西亚面临着严重的公共卫生挑战,原因是痛风和高尿血.
研究的目的:
- 确定法属波利尼西亚的痛风和高尿血病的流行率.
- 调查与饮食,并发症和HLA-B*58:01等位基因的关联.
- 评估当前的疾病管理战略.
主要方法:
- 一个前性的,横截面的,以痛风为重点的流行病学调查 (Ma'i u'u) 在法属波利尼西亚的随机成年人样本中.
- 通过2021年4月至8月的指导访谈收集的数据.
- 使用全基因组测序数据估计的HLA-B*58:01等位基因频率.
主要成果:
- 痛风的患病率估计为14.5% (25.5%在男性中,3.5%在女性中);高尿路血症为71.6%.
- 痛风的相关因素包括年龄较大,男性性别,血清尿酸水平较高,2型糖尿病,肥胖和内脏脂肪.
- HLA-B*58:01载体的低患病率 (总体为0.4%,在波利尼西亚祖先子组中为0.1%).
结论:
- 法属波利尼西亚的痛风和高尿路血的患病率很高,影响了成年人口的很大一部分.
- 紧急实施区域性措施,以改善获得尿酸降低疗法的机会,对公共卫生至关重要.
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