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深度大脑刺激和口头建议对帕金森病疼痛的影响

Sophie Rosenkjær¹, Victor Schwartz Hvingelby², Erik Lisbjerg Johnsen^3,4

¹Department of Psychology and Behavioural Sciences, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark.

Scandinavian journal of pain

|March 14, 2024

概括

在接受深度脑刺激 (DBS) 的帕金森病 (PD) 患者中,口头建议可能会影响疼痛,尽管刺激本身并没有改变疼痛. 在这项研究中,患者没有对刺激水平进行盲定.

科学领域:

神经科学是一个神经科学.
神经学神经学
疼痛管理疼痛管理

背景情况:

在帕金森病 (PD) 中,亚thalamic深脑刺激 (DBS) 调节了运动和临床结果.
DBS还可以缓解PD患者的疼痛.
口头建议对DPS介导的PD疼痛缓解的影响尚不清楚.

研究的目的:

调查口头建议是否会影响亚thalamic DBS 对帕金森病患者疼痛的影响.
评估不同DBS刺激水平和口头建议对疼痛感知和运动症状的综合影响.

主要方法:

24名患有DBS的PD患者在不同的日子接受了盲目的随机刺激,下调和上调.
参与者接受了与疼痛相关的负面/正面建议或没有建议 (控制).
疼痛 (持续和唤起),运动症状和患者的期望被使用数值评分尺度来评估.

主要成果:

亚thalamic DBS没有显著改变正在进行或引起的疼痛,但像预期的那样影响了运动症状.
一个趋势表明,负面建议增加了疼痛,而积极建议减少了疼痛.
在相同的刺激条件与对比的口头暗示之间观察到疼痛感知的显著差异 (p < 0.001).

结论:

脑下DBS可能不会直接影响PD的疼痛,但口头暗示可能在调节疼痛感知方面发挥作用.
患者识别刺激水平的能力影响了这项研究的盲目性,突出了未来研究的关键因素.

关键词:

帕金森病是帕金森病的一种疾病.深度大脑刺激刺激大脑疼痛疼痛疼痛疼痛避孕药效应对安慰剂的影响建议建议建议

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