自我报告的手术前抑郁症状和心脏手术后的存活率
Anna Falk1,2, Ulrik Sartipy1,3, Malin Stenman1,2
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
概括
心脏手术患者的手术前抑郁症状与较差的长期存活率有关. 识别和解决抑郁症对于改善心脏手术后患者的治疗结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 抑郁症是心血管疾病的已知危险因素之一.
- 心脏手术患者可能会出现手术前的抑郁症状.
- 在这个人群中,手术前抑郁症对长期生存的影响需要进一步研究.
研究的目的:
- 为了确定自己报告的手术前抑郁症状是否与接受心脏手术的患者的长期存活率较差有关.
- 量化抑郁和非抑郁的心脏手术患者之间的生存差异.
主要方法:
- 一项基于人口的观察性队列研究,对1120名心脏手术患者 (2013-2016) 进行了观察.
- 使用患者健康问卷 (PHQ-9) 进行手术前评估的抑郁症状,抑郁症定义为PHQ-9评分≥10.
- 权衡的灵活参数生存模型分析了抑郁症状和全因死亡率之间的关联,平均随访时间为7.2年.
主要成果:
- 14.5%的患者报告了手术前的抑郁症状.
- 调整后的分析显示,抑郁症患者的死亡风险比为1.66 (95%CI为1.09-2.54).
- 与非抑郁患者相比,抑郁患者在8年的绝对生存差异为-9.7%.
结论:
- 自我报告的手术前抑郁症状与心脏手术后的长期存活率较差显著相关.
- 抑郁症状应该被认为是心脏手术中与传统风险因素相比较的关键风险因素.
- 早期识别和治疗抑郁症可能会改善心脏手术患者的长期结果.
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