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一些新的lomofloxacin衍生物的设计,合成和体外抗癌活性

Mina E Adly1, Ehab M Gedawy2,3, Afaf A El-Malah2

  • 1Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt. mina.magharyos@pharma.cu.edu.eg.

Scientific reports
|March 15, 2024
PubMed
概括

新的lomofloxacin衍生物被合成以抑制topoisomerase II,显示出强大的抗癌活性. 化合物3e表现出显著的细胞循环停止和与多克索鲁比相似的拓酶II抑制.

关键词:
它具有抗癌活性.洛姆弗洛克萨辛 (Lomefloxacin) 是一种药物.托波异相酶II的存在

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