关于影响人类男性生殖道和生育能力的已知和新出现的病毒的最新情况
Sara Dabizzi1, Mario Maggi2,3, Maria Gabriella Torcia4,5
1Andrology, Women's Endocrinology and Gender Incongruence Unit, Center for the Prevention, Diagnosis and Treatment of Infertility, Azienda Ospedaliera Universitaria Careggi Hospital, Florence, Italy. dabizzis@aou-careggi.toscana.it.
Basic and clinical andrology
|March 15, 2024
概括
许多病毒通过损害生殖道和损害精子来损害男性生育能力. 从男性生殖道 (MGT) 持续流出病毒可能会导致长期的传播风险.
科学领域:
- 生殖免疫学 生殖免疫学
- 病毒学 病毒学
- 男人生殖健康 男人生殖健康
背景情况:
- 病毒感染可能会对男性生殖系统 (MGT) 和男性生育能力产生负面影响.
- 病毒性炎症引起的氧化应激会导致丸损伤,影响生殖细胞和内分泌细胞.
- 病毒感染MGT可以导致精子质量降低和DNA碎片化增加.
研究的目的:
- 审查有关影响MGT的病毒的证据.
- 检查病毒进入路径,生育能力的影响和精液流出模式.
- 描述实验室的策略,以防止在辅助生殖交叉感染.
主要方法:
- 关于男性生殖道病毒感染的文献综述.
- 病毒进入,病原和生育结果的分析.
- 检查精液中的病毒分泌模式.
- 对辅助生殖技术的实验室策略的审查.
主要成果:
- 病毒可以破坏MGT,通过氧化应激和炎症损害男性生育能力.
- 常见的副作用包括精子数量减少,运动性和DNA碎片化增加.
- MGT可以充当病毒储存库,具有持续的分泌和性传播风险.
- 像寨卡病毒和埃博拉病毒这样的新兴病毒强调了对幸存者的监视的需要.
结论:
- 病毒感染对男性生育能力和公共健康构成重大威胁.
- 由于MGT是病毒的储存库,因此需要新的监控方法.
- 实验室策略对于管理血清异性夫妇辅助生殖中的交叉感染风险至关重要.
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