炎症性肠病中的循环抵抗水平:系统性审查和元分析
Amir Hossein Behnoush1,2, Seyede Parmis Maroufi3, Tara Reshadmanesh4
1School of Medicine, Tehran University of Medical Sciences, Poursina St., Keshavarz Blvd, 1417613151, Tehran, Iran. amirhossein.behnoush@gmail.com.
BMC gastroenterology
|March 15, 2024
概括
在炎症性肠病 (IBD) 中,循环抵抗水平升高,包括性结肠炎和克罗恩病. 与健康个体相比,IBD的活跃阶段和缓解阶段都观察到较高的抵抗水平.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),是一种慢性胃肠道疾病,患病率越来越高.
- 脂质细胞和脂质蛋白,如抵抗素,与IBD特征的全身免疫反应有关.
研究的目的:
- 调查循环电阻水平与IBD的活性和缓解阶段之间的关联.
- 为了比较IBD患者的抗体水平与健康对照者的抗体水平.
主要方法:
- 从主要科学数据库 (PubMed,Embase,Web of Science,Scopus) 获取到2023年6月的研究的系统审查和随机效应元分析.
- 估计血/血清抵抗水平的标准化平均差异 (SMD) 和95%置信区间 (CI).
主要成果:
- 对19项研究 (1836例) 的分析显示,IBD患者与健康对照组相比,IBD患者的抵抗水平显著更高 (SMD1.33,p<0.01).
- 与缓解和健康对照人群相比,IBD在活性和缓解阶段均观察到较高的抵抗水平 (活性与缓解:SMD1.04,p=0.01;缓解与缓解). 身体健康:SMD 0.60,p<0.01). 在健康情况下:SMD 0.60,p<0.01).
- 这些发现对于UC和CD亚型一致.
结论:
- 在患有IBD (UC和CD) 的患者中,循环抵抗素水平显著增加.
- 与健康个体相比,即使在IBD的缓解阶段,也存在较高的抵抗水平.
- 需要进行进一步的研究,以阐明抗原在IBD病变发生过程中的特定作用.
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