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Updated: Jun 30, 2025

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对非热点KRAS突变及其作为有效癌症疗法的点潜力的结构性见解

Cong Ding1, Gaoyuan Wang1, Wenqing Zou1

  • 1Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.

Journal of biomolecular structure & dynamics
|March 15, 2024
PubMed
概括

基尔斯大鼠肉瘤病毒蛋白 (KRAS) 的非热点突变保持其致癌功能,不会引起耐药性. 这些KRAS突变可以被现有的FDA批准的抑制剂向,提供新的治疗策略.

关键词:
在KRAS和G12C中.这是一个KRAS突变基因.它们是有侵略性的.药物耐药性 耐药性 药物耐药性非热点突变的突变.这就是Sotorasib.

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