血清炎症标记物用于心血管疾病风险预测模型:系统性审查
Sofia-Panagiota Giannakopoulou1, Alexios Antonopoulos2, Demosthenes Panagiotakos1
1Department of Nutrition - Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Angiology
|March 15, 2024
概括
像C反应蛋白 (CRP) 这样的血清炎症生物标志物没有显著改善心血管疾病 (CVD) 风险预测模型. 这些标志物可能表明潜在的炎症,但不是动脉样硬化心血管疾病的独立预测因素.
科学领域:
- 生物医学科学 生物医学科学
- 心血管研究研究心血管研究
- 炎症生物学 炎症生物学
背景情况:
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 准确的风险预测对于有效的初级预防策略至关重要.
- 血清炎症生物标志物正在研究它们在心血管疾病风险评估中的潜在作用.
研究的目的:
- 批判性地评估关键血清炎症生物标志物对心血管疾病 (CVD) 风险预测的预后价值.
- 评估C-反应蛋白 (CRP),IL-6 (IL-6) 和瘤亡因子-α (TNF-α) 在没有确定的心血管疾病的个体中增加的预测能力.
- 评估将这些生物标志物整合到现有的CVD风险预测模型中的影响.
主要方法:
- 对MEDLINE和Scopus数据库进行系统审查 (2000年1月至2023年12月).
- 包括使用多变量预测模型在未知心血管疾病患者中评估CRP,IL-6,TNF-α的预后价值的研究.
- 使用预后研究质量 (QUIPS) 工具评估研究质量和偏差.
主要成果:
- 分析了35项涉及208,897名参与者的研究.
- 在 7/32 项研究中,C-反应蛋白 (CRP) 显示了心血管疾病风险预测的改善.
- 介质素-6 (IL-6) 在1/8的研究中改善了预测;TNF-α在评估的单一研究中没有增加价值.
- 总的来说,这些生物标志物的整合并没有持续增强心血管疾病风险歧视模型.
结论:
- 血清炎症生物标志物,包括CRP和IL-6,为预测动脉样硬化心血管疾病风险提供有限的附加值.
- 这些生物标志物可能反映了潜在的炎症过程,但似乎不是心血管疾病事件的独立预测因素.
- 目前的证据表明,已确定的风险因素仍然是心血管疾病风险分层的主要因素.
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