结直肠癌患者控制营养状况评分和临床生化指标之间的相关性研究
Zhi Wang1, Jin Bian2, Jiayan Yuan3
1Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Heliyon
|March 15, 2024
概括
控制营养状况 (CONUT) 评分可以改进,用于预测结直肠癌 (CRC) 的预后. 像白细胞 (WBC) 和中性粒细胞 (NE) 这样的额外指标提高了它的预测价值.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 生物统计学 生物统计学
背景情况:
- 控制营养状况 (CONUT) 评分是结直肠癌 (CRC) 的预后工具.
- 它对CRC预后的预测效果目前是不够的.
- 需要确定额外的临床指标,以提高CONUT评分的预测能力.
研究的目的:
- 确定可以补充CONUT评分系统的临床指标.
- 为了提高对结直肠癌 (CRC) 预后的CONUT得分的预测值.
主要方法:
- 从5014名CRC患者 (2014-2020年) 追溯收集临床数据.
- 基于血清白蛋白,淋巴细胞和总胆固醇的CONUT得分的计算.
- 评估CONUT得分与各种临床和免疫营养指标之间的相关性.
主要成果:
- 结肠癌与直肠癌患者,男性与女性,老年患者的营养状况较差.
- 营养不良与更长的住院时间相关.
- 与CONUT分数和CRC预后显著相关的指标包括白细胞 (WBC),中性粒细胞 (NE),单细胞 (MC),乙素细胞 (EOS),基细胞 (BAS) 和低密度脂蛋白 (LDL).
结论:
- CONUT评分是结直肠癌 (CRC) 的一个有价值的预后工具.
- 诸如白细胞 (WBC),中性粒细胞 (NE),单细胞 (MC),乙素 (EOS),基素 (BAS) 和低密度脂蛋白 (LDL) 等指标与CONUT得分显示出显著的相关性.
- 这些指标可以作为CONUT评分系统的宝贵补充,以更有效地预测CRC预后.
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