全球获取CAR-T细胞的挑战:亚洲视角
William Yk Hwang1,2, Satoshi Takahashi3, Bryan Choi4
1National Cancer Centre Singapore, Singapore.
Blood cell therapy
|March 15, 2024
概括
化学抗原受体 (CAR) T细胞疗法因制造成本高而面临采用障碍. 亚洲的策略,如患者辅助和现场生产,是有希望的,但大规模制造是全球可访问性的关键.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 细胞疗法细胞疗法
背景情况:
- 细胞疗法,特别是嵌合抗原受体 (CAR) T 细胞疗法,在瘤学中迅速发展.
- 包括高制造成本和基础设施需求在内的重大障碍阻碍了全球采用CAR-T疗法.
研究的目的:
- 审查在亚洲实施的战略,以克服CAR-T细胞疗法采用的障碍.
- 确定影响不同医疗保健系统中CAR-T细胞疗法的成本和可获得性的关键因素.
主要方法:
- 对亚洲国家在CAR-T细胞疗法实施方面采用的策略的审查.
- 分析方法,包括患者援助计划,资助者参与,成本效益研究和制造模型.
主要成果:
- 亚洲战略包括患者援助,资助者合作,成本效益分析和现场制造.
- 虽然现场制造可以降低一些成本,但它并不能解决所有隐藏的费用或质量问题.
结论:
- 由科学创新驱动的区域性大规模制造对于降低CAR-T治疗成本至关重要.
- 制造业的规模经济对于促进全球更广泛地获得这些先进的细胞疗法至关重要.
相关概念视频
01:40Cell-mediated Immune Responses
Overview
01:22T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.