在患有原发性胆道胆炎的患者中,sarcopenia的患病率和对预后的影响
Jiaqi Yang1, Shuangshuang Jiang1, Qingling Fan1
1Department of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Frontiers in medicine
|March 15, 2024
概括
麻症影响了25.9%的初级胆道胆炎 (PBC) 患者,增加了不良事件. 在PBC患者中早期检测和治疗肉类症可以改善结果和生活质量.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 临床营养学 临床营养学
背景情况:
- 皮症对肝硬化和NAFLD的治疗结果产生负面影响.
- 在一次性胆道胆道炎 (PBC) 中对肉类的研究是有限的.
- 这项研究调查了 Sarcopenia 的流行率及其在 PBC 患者的预后影响.
研究的目的:
- 为了确定在初级胆道胆道炎 (PBC) 患者中类病的患病率.
- 为了确定与PBC中肉类相关的危险因素.
- 为了评估缩症对PBC患者预后的影响.
主要方法:
- 腹部CT扫描被用来通过L3骨肌指数来评估sarcopenia.
- 基于中国人口的切断值被用于萨科佩尼亚诊断.
- 实验室值和肝硬度测量从电子医疗记录中收集.
主要成果:
- 在研究的174名PBC患者中,有25.9%的患者被诊断为肉症.
- 男性的性别和肝硬度测量 (LSM) ≥12.8kPa是萨尔科佩尼亚的独立风险因素.
- 在PBC患者 (HR=4.058,p<0.001) 中,萨科佩尼亚是不良事件的显著风险因素.
结论:
- 在PBC患者中 Sarcopenia是普遍存在的,并且与较差的结果相关.
- 综合评估和治疗皮症对于改善PBC患者的治疗结果和生活质量至关重要.
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