患有需要再血管化的阻塞性冠状动脉疾病的女性心血管危险因素的患病率:元分析
Léa Berbach1,2, Claudia Nelsa Atongfor Nguéfack1,2, Brian J Potter1,2,3
1Faculty of Medicine, University of Montreal, Montréal, Québec, Canada.
CJC open
|March 15, 2024
概括
与男性相比,接受冠状动脉旁路移植 (CABG) 和皮肤冠状动脉干预 (PCI) 等心血管手术的女性患高血压和糖尿病的比例更高. 这突显了女性心血管风险因素的严重差异.
科学领域:
- 心脏病学 心脏病学
- 血管外科 血管外科
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 是导致女性过早死亡的首要原因,这一人口在临床试验中历史上代表性不足.
- 接受冠状动脉旁路移植 (CABG) 和皮肤冠状动脉干预 (PCI) 的女性比男性表现出更高的基线心血管风险因素,增加的术后并发症和更高的死亡率.
研究的目的:
- 进行综合性分析,比较经过重血管化手术的男性和女性之间个别心血管风险因素的流行率.
主要方法:
- 对原始调查进行了元分析,涉及了接受手术干预或PCI的成年受试者.
- 通过使用来自MEDLINE,Cochrane,EBMR,Ovid Embase,Google Scholar和PubMed数据库的数据来评估心血管风险因素.
主要成果:
- 分析包括18项研究,显示女性高血压 (CABG: 71%,PCI: 59%) 和糖尿病 (CABG: 48%,PCI: 43%) 的高患病率.
- 与男性相比,女性患高血压 (CABG 的OR为1.92,PCI 的OR为1.86) 和糖尿病 (CABG 的OR为1.94,PCI 的OR为1.97) 的几率明显高.
- 相反,在接受这些手术的女性中,吸烟的发生率较低 (CABG:0.17,PCI:0.22).
结论:
- 与男性相比,接受CABG或PCI的女性患高血压和糖尿病的可能性明显更高.
- 这些发现强调了在对女性心血管疾病的管理和风险评估中需要考虑性别特异性的需要.
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