在被诊断为急性冠状动脉综合征的患者中,光学一致性断层扫描血管学变化:系统性审查和元分析
Anna Maria Sideri1, Dimitra Mitsopoulou1, Stylianos A Kandarakis1
1First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC.
光学连贯断层扫描血管学 (OCTA) 度量显示,急性冠状动脉综合征 (ACS) 患者和健康人群之间没有显著差异. 这次系统性审查和元分析发现ACS患者的斑点没有明显的OCTA参数变化.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 医疗成像医学成像
背景情况:
- 急性冠状动脉综合征 (ACS) 是一种严重的心血管疾病.
- 光学连贯断层扫描血管造影 (OCTA) 是一种先进的成像技术,可视化视网膜血管结构.
- 评估系统性疾病和眼部发现之间的潜在联系对于全面的患者护理至关重要.
研究的目的:
- 对OCTA参数与ACS之间的关联进行系统审查和元分析现有研究.
- 为了确定在ACS和健康对照对象之间,斑点中的OCTA指标是否不同.
主要方法:
- 从开始到2023年4月,对多个电子数据库进行了全面的搜索.
- 包括的研究是观察性,随机对照性试验,以及涉及成人ACS患者的注册/数据库研究.
- 使用随机效应模型计算了95%置信区间的聚合标准化平均差异 (SMD),并通过I2和Cochran Q统计评估异质性.
主要成果:
- 系统性审查包括7项研究 (n=898),其中3项研究 (n=341) 参与了元分析.
- 在ACS患者和健康对照者之间,对于表面血管 (SVP) (SMD: -0.46,p=0.05),深血管 (DVP) (SMD: -0.10,p=0.75) 或状血管区 (FAZ) (SMD: 0.43,p=0.38) 的聚合SMD没有发现显著差异.
- 对于SVP (I2=0%) 和DVP (I2=67%),观察到的异质性较低,而对于FAZ (I2=92%),观察到的异质性较高.
结论:
- 目前的证据表明,急性冠状动脉综合征患者和健康人群之间黄斑OCTA参数没有显著差异.
- 用标准化的方法进一步研究可能是有必要的,以探索微妙的关联.
- 基于当前的数据,OCTA可能不能作为识别ACS的主要诊断工具.
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