miR-146a是一个关键的目标,与多种皮肤衰老的生物途径有关
Klodjan Stafa1, Antonella Rella1, Whitby Eagle1
1Research and Development, The Estée Lauder Companies, Melville, NY, United States.
Frontiers in physiology
|March 15, 2024
概括
微RNA-146a (miR-146a) 的表达随着年龄的增长而下降,影响皮肤衰老和昼夜节律. 阿丹索尼亚数字提取物增强了miR-146a,促进了皮肤健康.
科学领域:
- 皮肤病学 皮肤病学
- 分子生物学分子生物学
- 时间生物学 时间生物学
背景情况:
- 皮肤衰老涉及复杂的表观遗传调节,包括微RNA.
- 微RNA-146a (miR-146a) 与炎症有关,但其在皮肤衰老中的作用尚不清楚.
- 循环节律影响皮肤屏障功能和修复过程.
研究的目的:
- 研究miR-146a在皮肤纤维细胞中在衰老过程中的作用.
- 探索miR-146a和昼夜节律基因之间的关联.
- 为了评估Adansonia digitata提取物对miR-146a表达和皮肤衰老标志物的作用.
主要方法:
- 分析了来自不同年龄的捐赠者的人类皮肤纤维细胞中的miR-146a表达.
- 使用抑制剂和Adansonia digitata提取物调节的miR-146a水平.
- 评估了细胞增殖,原-1生产,炎症标记物和时钟基因表达.
主要成果:
- 在皮肤纤维细胞中,miR-146a的表达随着年龄的增长而下降.
- miR-146a抑制改变了时钟基因表达,这表明与昼夜节律的联系.
- 降低miR-146a的调节减少了增殖和原-1,同时增加了DNA损伤和炎症.
- 阿丹索尼亚数字提取物抵消了miR-146a抑制的负面影响,并增强了外体miR-146a转移.
结论:
- miR-146a是皮肤衰老途径的关键调节者,包括昼夜节律和原蛋白生产.
- miR-146a影响细胞增殖,DNA修复和炎症.
- 阿丹索尼亚数字提取物通过上调miR-146a.显示了促进皮肤健康的潜力.
更多相关视频
08:40Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
17.6K
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
1.9K
相关概念视频
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
01:12Renewal of Skin Epidermal Stem Cells
2.5K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.5K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K