在SARS-CoV-2疫苗接种或感染后,纵向类风湿因子自身抗体反应
Sofie Keijzer1,2, Nienke Oskam1,2, Pleuni Ooijevaar-de Heer1,2
1Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, Netherlands.
Frontiers in immunology
|March 15, 2024
概括
在COVID-19疫苗接种或感染后,类风湿因子 (RF) 反应不常见,在一项大型研究中观察到新的RF发展率较低. 这表明,疫苗接种和感染通常都不会引发显著的RF表皮质传播.
科学领域:
- 免疫学 免疫学 免疫学
- 这是一种自身免疫力.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 类风湿性因素 (RFs) 是针对IgG的自身抗体,存在于类风湿性疾病和健康个体中.
- 免疫触发器,如疫苗接种或感染,可能会引起射频反应,但数据是相互矛盾的.
- 了解疫苗接种/感染后的射频动态对于解释自身免疫反应至关重要.
结论:
- 接种疫苗或感染后的RF诱导很少发生.
- 观察到的射频响应通常是低水平的,并没有表明表位扩散.
- 这项研究澄清了SARS-CoV-2疫苗接种和感染后射频诱导的低发病率.
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