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型肝炎病毒感染和与医院相关的结果:系统性审查
Michelle Ng1, Patrizia Maria Carrieri2, Lindila Awendila3
1British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, British Columbia, Canada V6Z 2A9.
Canadian journal of gastroenterology & hepatology
|March 15, 2024
概括
型肝炎感染 (HCV) 显著增加住院和住院时间. 直接作用抗病毒药物 (DAA) 在减少这些结果方面表现有希望,但需要更多的研究来确认它们的全部影响.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 医疗保健服务研究 医疗服务研究
背景情况:
- 型肝炎病毒 (HCV) 感染对全球医疗保健系统造成了巨大的负担,其特点是住院服务的利用率很高.
- 感染HCV对医院结局的影响尚不清楚,特别是直接作用抗病毒药物 (DAA) 的潜在影响.
研究的目的:
- 系统地审查有关HCV感染对医院相关结果的影响的现有文献.
- 调查DAA如何改变HCV感染和医院结局之间的关系.
主要方法:
- 截至2022年8月,对五个数据库进行了全面搜索.
- 包括的研究进行了相关性选,删除重复的内容,并从57篇选定的文章中提取数据.
主要成果:
- 感染HCV与住院病例的增加,住院时间的延长和再入院率的提高有关.
- 将HCV与住院死亡率联系在一起的证据不那么一致.
- 对DAA进行的有限研究表明,住院和死亡率有所降低.
结论:
- 高质量的证据证实,HCV会对医院结果产生负面影响,主要是增加入院,停留时间和再入院.
- 进一步的研究是必不可少的,以充分阐明DAA对医院相关结果的影响,由于目前可用的研究数量有限.
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