血管的生物标志物的进展 - - 面向未来的基于血液的诊断测试
Aditya M Mittal1, Kamil W Nowicki2, Rohit Mantena1
1University of Pittsburgh Medical Center, Department of Neurosurgery, Pittsburgh, PA, USA.
World neurosurgery: X
|March 15, 2024
概括
在下大脑下出血 (SAH) 后开发脑血管的血液测试至关重要. 这可以改善早期检测,并减少因延迟性脑梗塞的死亡率.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 医学诊断 医学诊断 医学诊断
背景情况:
- 大脑血管和延迟性脑梗塞是动脉瘤下arachnoid出血 (SAH) 后死亡的主要原因.
- 目前的检测方法涉及侵入性或昂贵的成像,带来风险和财务负担.
- 缺乏基于血液的测试来诊断血管.
研究的目的:
- 审查关于脑血管和延迟脑缺血机制的文献,重点关注炎症.
- 为开发用于检测血管的假设血液测试提供理由.
- 突出需要临床翻译研究来创建这样的诊断工具.
主要方法:
- 在PubMed,Web of Science和Embase数据库 (1997-2022) 的系统文献搜索.
- 包括关于脑血管,动脉瘤破裂和生物标志物的研究.
- 数据提取和资格研究的总结.
主要成果:
- 对632个引文进行初步选.
- 217个摘要被选中进行审查.
- 59篇全文文章符合资格标准,其中13篇被排除在外.
结论:
- 总结了目前对血管和延迟脑缺血的理解,强调了炎症的作用.
- 提出未来基于血液的测试作为一个关键的诊断进步.
- 倡导临床翻译努力开发和实施这种测试,以改善患者的治疗结果和降低死亡率.
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