左心房形状作为心房肌病的标志物在不确定的来源的栓塞性中风中
Aaisha Ferkh1,2, Kasun De Silva1,2, Jennifer Pham2
1Westmead Clinical School, University of Sydney, Darcy Road, Westmead, NSW 2145, Australia.
European heart journal. Cardiovascular Imaging
|March 15, 2024
概括
左心房 (LA) 肌病,以增加LA球性为特征,存在于源不明 (ESUS) 的栓塞性中风和心栓塞性 (CE) 中风患者中. 这些LA形状的改变可能有助于在ESUS中识别LA肌病,以改善二次预防.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 源不明的栓塞性中风 (ESUS) 对与中风相关的发病率有显著的贡献.
- 左心房 (LA) 肌病越来越多地被认为是ESUS的潜在贡献者.
- 了解LA结构的变异可能会阐明中风病因.
研究的目的:
- 为了研究源不明的栓塞性中风 (ESUS) 和心栓塞性 (CE) 中风之间的左心房 (LA) 形状的差异.
- 在ESUS患者中识别潜在的LA肌病标志物.
主要方法:
- 有望招募236名患有缺血性中风的患者和对照组.
- 对心房 (AF) 的分类为 Paroxysmal AF (PAF) 和持久性AF (PersAF).
- 对LA体积,功能和形状指数 (3D LA球性,2D LA圆性,圆性,球性,离心率) 的心声评估.
主要成果:
- 与对照组相比,CE,AF和ESUS组观察到增加LA体积,球状性和功能障碍.
- K-means集群分析揭示了LA肌病的频谱,ESUS,PAF和CE-PAF患者在对照组和持久性AF组之间.
- 经过对共变量进行调整 (P < 0.01) 后,LA球状性标记物显著区分ESUS与对照物.
结论:
- 在ESUS,AF和CE患者中,LA形状的显著变化,特别是球形重塑,是显而易见的.
- 新的LA球性标志物在ESUS人群中发现LA肌肉病的有希望.
- 这些发现可能会为ESUS患者的二次预防策略提供信息.
关键词:
超声心电图 (Echocardiography) 是一种心声回声仪.左心房的功能是左心房功能.左心房肌病症 左心房肌病症左心房的形状 左心房的形状左心房的球形性左心房应变是左心房应变.在左心房的左心房.更多相关视频
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