在REGARDS研究中,细胞因子,C反应蛋白和发生高血压的风险
Timothy B Plante1, Stephen P Juraschek2, George Howard3
1Departments of Medicine (T.B.P., D.K.M., N.A.Z., M.C.), Larner College of Medicine at the University of Vermont, Burlington, VT.
Hypertension (Dallas, Tex. : 1979)
|March 15, 2024
概括
较高水平的互白素-1β,瘤亡因子-α和干扰素-γ与高血压风险的增加有关. 这些炎症标志物可以预测未来高血压的发展.
科学领域:
- 心血管疾病流行病学
- 炎症生物标志物和高血压
- 公共卫生和慢性疾病预防 预防
背景情况:
- 高血压是心血管疾病的主要危险因素.
- 炎症与高血压的发展有关.
- 炎症性细胞因子和高血压风险之间的特定关系尚未完全理解.
研究的目的:
- 研究特定炎症性细胞因子水平升高与患高血压的风险之间的关联.
- 检查介质素 (IL) - 1β,IL-6,瘤亡因子 (TNF) -α,干扰素 (IFN) -γ,IL-17A和C反应蛋白 (CRP) 是否预测发生的高血压.
主要方法:
- 一项前性队列研究 (REGARDS),有1866名没有患高血压的参与者.
- 在基线后大约9年后的后续评估.
- 普森回归用于根据炎症生物标志物水平估计发生高血压的风险比率.
主要成果:
- 较高的IL-1β水平与白人参与者的高血压风险增加有关.
- 在所有参与者中,TNF-α和IFN-γ水平升高与发生性高血压的风险增加有关.
- 在IL-6,IL-17A或CRP水平与患高血压的风险之间没有发现显著的关联.
结论:
- 高水平的IL-1β,TNF-α和IFN-γ先于高血压的发展,表明明显的炎症途径.
- 这些发现表明,高血压风险预测的潜在生物标志物.
- 需要进一步的研究来确定是否针对这些细胞因子可以减少高血压的发生率.
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