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含有较高同样化氨基酸的天然产品

Skyler L Owens¹, Shopno R Ahmed¹, Rebecca M Lang Harman¹

¹Department of Chemistry and Biochemistry, Augusta University, 1120 15th Street, Augusta, GA 30912.

Chembiochem : a European journal of chemical biology

|March 15, 2024

概括

本综述探讨了含有同类氨基酸 (homoAAs) 的天然产品,详细介绍了它们的生物合成. 了解这些途径为药物发现和代谢工程提供了潜力.

科学领域:

自然产品化学自然产品化学
生物化学生物化学
合成生物学合成生物学

背景情况:

自然产品 (NP) 可以含有非蛋白质原性氨基酸,特别是同类氨基酸 (homoAAs),其侧链中具有插入的甲基.
同类AAA的生物合成在自然界中并不常见,大约有450个含有同类AA的NP在细菌,真菌和动物类中被确定.

研究的目的:

审查包含homoAAs的NP,并讨论它们的特征或拟议的生物合成途径.
要突出经过同质化的氨基酸的多样性以及涉及的多种酶机制.

主要方法:

关于天然产品和氨基酸生物合成的科学出版物的文献评论.
对已知的homoAA结构及其相关生物合成途径在不同生物体中的分析.
对不同氨基酸类型和生物王国中homoAA形成的酶途径的比较.

主要成果:

已发现十种氨基酸 (氨酸,氨酸,氨酸,氨酸,氨酸,氨酸,氨酸,氨酸,氨酸,氨酸,氨酸,氨酸,氨酸) 在NP中均.
特定的氨基酸如异黄素,素,氨酸和氨酸共享共同的酶途径,而其他氨基酸则具有独特或不太了解的酶途径.
同类AAs的生物合成是多样化的,在细菌和真菌中观察到不同的路径,一些氨基酸 (氨酸,氨酸) 缺乏报告的路径.

结论:

自然产品中的homoAAs的生物合成为未来的组合生物合成和代谢工程研究提供了重大机会.
进一步探索这些途径可能会开辟新的药物发现途径,因为含有homoAA的NP的独特结构.

关键词:

氨基酸是氨基酸的组成部分.生物合成生物合成认同认证认同认证自然产品自然产品酸是一种酸.

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