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通过调节Nrf2/HO-1通路活性来改善性结肠炎:整合动物实验和网络药理学

Xinya Yu¹, Xiaoxi Li², Yunchun Xu¹

¹Department of Medical Microbiology and Immunology, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China.

Molecular medicine reports

|March 15, 2024

概括

复星 (Res) 通过激活Nrf2/HO-1通路,有效地治疗小鼠的性结肠炎 (UC). 这种天然化合物减少炎症,改善肠道屏障功能,缓解UC症状,显示治疗潜力.

科学领域:

胃肠病学胃肠病学
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病,其特点是肠壁功能障碍.
与核素红色素-2相关的2因子/血氧酶1 (Nrf2/HO-1) 途径在调节抗氧化和抗炎反应方面发挥着至关重要的作用.
复星 (Res) 是一种天然的多,具有已知的抗炎和抗氧化特性.

研究的目的:

为了研究Resveratrol对小鼠实验性性结肠炎的治疗作用.
为了确定resveratrol是否在UC治疗的背景下调节Nrf2/HO-1信号通路.
阐明resveratrol缓解UC相关病理的潜在机制.

主要方法:

实验性性结肠炎在小鼠中使用硫酸 (DSS) 诱导.
评估了疾病活动指数 (DAI),组织病理学 (H&E染色) 和炎症性细胞因子水平 (IL-6,IL-1β,TNF-α,IL-10).
紧结蛋白 (ZO-1,Occludin) 和Nrf2/HO-1通路组件的表达被评估使用免疫组织化学和西欧斑块.
网络药理学和分子对接被用来确定关键目标和结合性亲和关系.

主要成果:

Resveratrol治疗显著降低了DAI,并改善了结肠组织病理损伤,包括密室损失和炎症透.
Ресвератрол降低了促炎性细胞因子水平 (IL-6,IL-1β,TNF-α) 和增加了抗炎性细胞因子水平 (IL-10).
Resveratrol恢复了紧结蛋白ZO-1和Occludin的表达,增强了肠道屏障的完整性.
复星的使用提高了Nrf2和HO-1的蛋白质表达,表明Nrf2/HO-1通路的激活.

结论:

Resveratrol在性结肠炎的实验模型中显示出显著的治疗疗效.
激活Nrf2/HO-1通路是Resveratrol在UC中的抗炎和保护作用的关键机制.
ресвератрол改善了肠道屏障功能,并减少了结肠炎症,突出了其作为治疗性结肠炎的潜力.

关键词:

Nrf2/HO-1 路径中的一个.实验性性结肠炎的研究.肠道粘膜屏障肠道粘膜屏障肠道粘膜屏障复星醇是一种复星醇.紧密的交叉路口紧密的连接

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