中等强度组合训练诱导肥胖和2型糖尿病患者的脂质学变化
Renata Garbellini Duft1,2,3, Ivan Luiz Padilha Bonfante2, Susana Alejandra Palma-Duran1,4
1Department of Metabolism, Digestion & Reproduction, Imperial College London, London SW7 2AZ, UK.
联合训练 (CT) 改善脂质代谢,减少肥胖和2型糖尿病 (T2D) 患者的不健康脂肪和胰岛素抵抗 (IR). 这种运动干预可以促进更健康的脂质组,而无需改变饮食.
科学领域:
- 代谢健康 代谢健康
- 运动生理学 运动生理学
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 脂质代谢的改变与胰岛素抵抗 (IR),肥胖和2型糖尿病 (T2D) 等代谢障碍有关.
- 综合训练 (CT),融合有氧 (AT) 和阻力 (RT) 运动,是已知的代谢健康的非药物治疗方法.
- 适度强度运动对身体的影响
研究的目的:
- 为了研究16周CT程序对血和白脂肪组织脂质谱的影响.
- 分析正常体重,肥胖 (OB) 和T2D的中年个体的性别特异性脂质组变化.
- 为了将运动引起的脂质变化与身体组成和代谢标记物的变化相关联.
主要方法:
- 一个为期16周的CT程序,包括8-10个RT练习,然后是35分钟的AT (45%-70%VO2max),每周3次.
- 超高性能液态染色体质谱学 (UHPLC-MS) 非向的脂质组学,用于全面的脂质分析.
- 评估身体成分,VO2max,强度,以及干预前后的生化标志物.
主要成果:
- CT显著降低了和脂肪酸和单不和脂肪酸在斯芬戈脂质,糖脂质 (GL) 和糖脂质 (GP).
- 在GP和GL中观察到培训后多不和脂肪酸水平的增加.
- 脂肪质量,身体周长,IR,无脂肪质量,VO2max和力量的显著改善被注意到 (P < .05).
结论:
- 16周的中度强度CT有效地重塑了肥胖和T2D患者的脂质代谢.
- 运动引起的脂质标记物变化与改善胰岛素抵抗和减少与肥胖相关的并发症的机制有关.
- 即使没有饮食修改,CT也是一种可行的策略,可以促进更健康的脂质组和减轻代谢功能障碍.
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