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在BRCA1/2突变载体中减少卵巢癌风险和查

Jessica B DiSilvestro¹, Jessica Haddad², Katina Robison¹

¹Department of Obstetrics-Gynecology, Program in Women's Oncology, Women and Infants Hospital, Providence, Rhode Island, USA.

Journal of women's health (2002)

|March 15, 2024

概括

女性BRCA1/2携带者接受了降低风险的手术,但接受药物治疗或卵巢癌查的人少. 需要进一步的研究来了解高风险妇女中这些预防策略的障碍.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
预防医学预防医学

背景情况:

BRCA1/2突变显著增加卵巢癌的风险.
风险降低策略和查对于早期检测和预防至关重要.
了解使用模式可以为高风险个体的临床实践提供信息.

研究的目的:

评估风险降低策略和卵巢癌查方案的采用情况.
评估影响女性BRCA1/2携带者使用这些预防措施的因素.
确定实施卵巢癌风险管理的潜在障碍.

主要方法:

在女性BRCA1/2突变携带者中进行了一项多中心的横截面调查.
电子问卷收集了关于降低风险的手术,药物 (组合口服避孕药) 和查的数据.
用费舍尔精确测试分析数据,以比较利用率.

主要成果:

几乎所有参与者 (97.1%) 与提供者讨论了降低风险的手术.
在45岁前接受测试的女性中,53.2%被建议服用联合口服避孕药 (COCs) 来降低风险,其中88.1%使用这些避孕药.
大约一半 (55.8%) 接受了增加的卵巢癌查,81.0%接受了查,通常是通过阴道超声波和CA125.5进行查.
在基因检测中,年轻女性的COC推率更高 (p < 0.0001).

结论:

虽然降低风险的手术被广泛提供,但降低风险的药物和查吸收率在BRCA1/2携带者中较低.
基因测试时的年龄会影响组合口服避孕药的推和使用.
在这种高风险人群中使用降低风险策略的障碍需要进一步调查.

关键词:

这就是BRCA BRCA.癌症查癌症查遗传咨询遗传咨询遗传咨询卵巢癌是发生在卵巢的癌症.风险管理风险管理

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