儿科慢性鼻炎的生物疗法:系统性审查
Sara Rahavi-Ezabadi1, Sheng Zhou2, Stella E Lee3
1Department of Otorhinolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
概括
对于儿科慢性鼻炎与鼻多重症 (CRSwNP) 的生物疗法存在有限的研究. 虽然对统一的呼吸道有希望,但需要更多的临床试验才能在儿童中更广泛地使用.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性鼻炎与鼻多重症 (CRSwNP) 显著影响儿童的生活质量.
- 生物疗法已在成人CRSwNP和儿科疾病,如喘和亚托邦性皮肤炎中显示出有效性.
- 目前对儿科CRSwNP生物使用的证据有限.
研究的目的:
- 审查目前对被诊断患有CRSwNP的儿童进行生物治疗的证据.
- 确定现有的研究和临床试验,调查儿科CRSwNP的生物制剂.
- 评估生物药物在治疗儿科CRSwNP中的潜在作用.
主要方法:
- 使用PubMed,MEDLINE,Cochrane和临床试验注册表进行了全面的文献搜索.
- 使用了与生物疗法和儿科CRSwNP相关的关键搜索术语.
- 审查的重点是确定专门针对该人群中的生物药物的研究和试验.
主要成果:
- 确定了针对儿科CRSwNP的生物药物的有效临床试验和研究显著缺乏.
- 一个正在进行的Dupilumab在患有鼻的儿童中的同情使用试验被注意到.
- 只有一个已发表的研究专门研究了在阿司匹林恶化呼吸道疾病的背景下针对儿科CRSwNP的Dupilumab.
结论:
- 目前对儿科CRSwNP生物治疗的证据很少.
- 生物药物显示出对患有CRSwNP的儿童统一呼吸道的管理有前途.
- 进一步的III期临床试验至关重要,以扩大儿科CRSwNP中生物药物的适用性,特别是对于那些患有并发症的人.
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