轨道_9:替代性评估:古典性与功能性低激素症-来自9年研究的知识
Michael Zitzmann1, Jann-Frederik Cremers1, Claudia Krallmann1
1Centre of Reproductive Medicine and Andrology of the University, Muenster, Germany.
Andrology
|March 15, 2024
概括
激素疗法 (TTh) 在下男性中显示出各种长期影响. 功能性阴性恋症 (FH) 患者的体重减轻和症状改善更大,但与经典性阴性恋症 (CH) 相比,血红素和PSA水平升高的风险也更高.
科学领域:
- 内分泌学 在内分泌学.
- 男人的健康 男人的健康
- 临床研究 临床研究
背景情况:
- 对于功能性阴性双胞胎症 (FH) 的丸激素治疗 (TTh) 的纵向数据有限.
- 了解TTh在不同的下腺病因方面的疗效至关重要.
研究的目的:
- 评估TTh在FH男性的长期疗效和临床效用.
- 为了比较FH和古典性阴性腺体缺陷症 (CH) 患者之间的TTh结果.
主要方法:
- 这是一项为期9年的注册研究,对650名男性进行了测试.
- 包括188名FH患者和462名CH患者 (原发性和二次性阴性腺瘤).
- 所有患者都接受了肌肉内测试非酸盐 (1000毫克);对人类,代谢和安全参数进行比较分析.
主要成果:
- 在FH和CH组中,TTh增加了血清丸激素水平,并导致体重和腰围的减少.
- FH患者的体重/腰部减少更大,但血红素和PSA增加的风险也更高.
- FH患者在代谢参数和症状得分 (AMS,IIEF-EF) 中表现出更明显的改善.
结论:
- 对于TTh的治疗结果,在所有阴茎下的人群中是异质的.
- 答案受到诊断类别,年龄和基线风险因素的显著影响.
- TTh的影响因年龄和初始体重而有所调节,FH和CH之间存在显著差异.
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