Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cancer Survival Analysis01:21

Cancer Survival Analysis

345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

8.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.9K
What is Cancer?02:12

What is Cancer?

10.7K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
10.7K
Cancer Therapies02:49

Cancer Therapies

7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Managing, Analyzing and Sharing Research Data with Gen3 Data Commons.

Scientific data·2026
Same author

Laying the Foundation for Clinically Actionable Genomic Subtyping in Diffuse Large B-cell Lymphoma.

Blood cancer discovery·2026
Same author

The importance of studying sex and gender in cancer research: Why and how.

Cancer·2026
Same author

In search of truth: evaluating concordance of AI-based anatomy segmentation models.

Journal of medical imaging (Bellingham, Wash.)·2026
Same author

Building Pediatric Cancer Cohorts and Accessing Data Using Childhood Cancer Data Initiative Tools.

JCO clinical cancer informatics·2025
Same author

GDC Cohort Copilot: an AI copilot for curating cohorts from the genomic data commons.

Bioinformatics advances·2025

相关实验视频

Updated: Jun 30, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K

NCI癌症研究数据共享:分享癌症关键数据的资源

Zhining Wang1, Tanja M Davidsen1, Gina R Kuffel2

  • 1Center for Biomedical Informatics and Information Technology, NCI, Rockville, Maryland.

Cancer research
|March 15, 2024
PubMed
概括

美国国家癌症研究所.

更多相关视频

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.7K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.6K

相关实验视频

Last Updated: Jun 30, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.7K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.6K

科学领域:

  • 在瘤学瘤学.
  • 生物信息学是一种生物信息学.
  • 数据科学数据科学数据科学

背景情况:

  • 国家癌症研究所 (NCI) 在2014年建立了癌症研究数据共享 (CRDC).
  • CRDC是一个生态系统,旨在容纳各种数据集,包括基因组,蛋白质组,成像和临床数据.
  • 主要目标是支持癌症研究,并促进NCI资助研究的数据共享.

研究的目的:

  • 审查CRDC生态系统中的各种数据共享.
  • 描述它们的独特和共同的特点,成就和挑战.
  • 讨论可查找,可访问,可互操作,可重复使用 (FAIR) 原则的实施和促进数据共享,与NIH数据管理和共享政策保持一致.

主要方法:

  • 审查现有的NCI数据共享:基因组数据共享 (GDC),蛋白质组数据共享 (PDC),综合犬类数据共享 (ICDC),癌症数据服务 (CDS),成像数据共享 (IDC) 和临床和翻译数据共享 (CTDC).
  • 分析每个数据共享的独特和共享的特性,成就和挑战.
  • 评估FAIR原则的实施和数据共享战略.

主要成果:

  • 提供了六个NCI数据共享的详细描述.
  • 审查强调了这些平台的独特能力和共同点.
  • 讨论了管理和共享这些多样化的数据集所遇到的成就和挑战.

结论:

  • CRDC数据共享提供了一个强大的基础设施,用于癌症研究数据.
  • 这些公共资源正在积极实施FAIR原则,以提高数据的可发现性和可用性.
  • 该CRDC支持NIH数据管理和共享政策,促进更广泛地获取NCI资助的研究数据.