2012年至2021年糖尿病眼病研究的全球趋势
Yuan Yuan1, Shangli Ji2,3, Yali Song4
1Aier School of Ophthalmology, Central South University, Changsha, Hunan Province, China.
Neural regeneration research
|March 15, 2024
概括
糖尿病眼病的研究主要由糖尿病视网膜病变主导,美国是主要的资金和出版物. 然而,在过去的十年里,很少有新的治疗方法或药物从这项研究中出现.
科学领域:
- 眼科和公共卫生.
- 糖尿病眼病的全球健康研究趋势
背景情况:
- 糖尿病眼病,包括糖尿病视网膜病变,黄斑,白内障和绿内障,构成了全球重大健康挑战.
- 糖尿病眼病的全球流行病学和研究格局仍然不完全表征.
研究的目的:
- 分析2012年至2021年糖尿病眼病的全球研究资金,产出和临床试验活动.
- 确定研究重点,国际合作和糖尿病眼部并发症药物开发的趋势.
主要方法:
- 对研究资助,期刊文章 (Web of Science,PubMed),临床试验 (ClinicalTrials.gov) 和药物批准 (美国,中国,日本,欧盟) 的系统搜索.
- 分析了来自七个代表国家的数据:美国,中国,日本,英国,西班牙,德国和法国.
- 资金分配的定量评估,出版指标,引用影响和临床试验重点.
主要成果:
- 糖尿病视网膜病变获得了大多数 (89.53%) 的研究资助,其次是糖尿病黄斑 (9.27%).
- 美国在研究资金和出版成果方面处于领先地位,与英国有着重要的国际合作.
- 糖尿病黄斑是临床试验的主要目标 (58.19%),近一半专注于血管生成;然而,眼科和糖尿病眼病的药物批准率非常低 (分别为2.19%和0.02%).
结论:
- 尽管大量的研究资金,特别是对于糖尿病视网膜病变,在糖尿病眼病的基础和翻译研究已经产生了有限的新疗法和批准的药物在过去十年.
- 这些发现突出了研究投资和临床转化之间在治疗糖尿病眼部并发症方面的潜在差距.
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