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纤维化变化与与代谢功能障碍相关的脂肪性肝病患者肝脏相关事件之间的关联
Hye Won Lee1,2,3, Kun Hee Kim1, Sang Hoon Ahn1,2,3
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
三年来肝硬度测量 (LSM) 的变化预测了代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的肝硬化或肝细胞癌 (HCC) 风险. 定期的LSM监测对于评估纤维化负担和患者的结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 非酒精性脂肪肝疾病研究研究
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的预后受到肝纤维化进展的显著影响.
- 肝硬度测量 (LSM) 是评估MASLD肝纤维化的关键非侵入性生物标志物.
- 了解LSM的动态变化对于预测不良临床结果至关重要.
研究的目的:
- 为了研究三年间肝硬度测量 (LSM) 纵向变化与MASLD患者肝硬化或肝细胞癌 (HCC) 的发展之间的关联.
- 确定LSM动态对于MASLD的长期临床结果的预测价值.
主要方法:
- 一组1738名MASLD患者在基线和三年后 (2012-2020年) 接受过渡性弹性图.
- 患者被分为低 (<8 kPa),不确定的 (8-12 kPa) 和高 (>12 kPa) LSM组.
- 肝硬化或HCC的发病率是基于LSM变化和其他风险因素 (如血小板计数) 计算的.
主要成果:
- 在1738名患者中,150名 (8.6%) 患有肝硬化或HCC.
- 在三年内,在LSM类别中观察到显著的变化,从不确定的和高到低类别的转移,反之亦然.
- 肝硬化或HCC的较高发病率与随着时间的推移增加的LSM类别 (例如,H→H组:每1000人年93.9) 和低血小板计数密切相关.
结论:
- 肝硬度测量 (LSM) 的纵向变化是MASLD患者临床结果的重要预测因素,包括肝硬化和HCC发展.
- 定期监测LSM值对于有效评估纤维化负担和管理MASLD患者至关重要.
- 与血小板计数一起,LSM动态为MASLD中的风险分层和个性化管理策略提供了宝贵的见解.
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