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相关概念视频

The Cochlea01:13

The Cochlea

44.8K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
44.8K
Hair Cells01:22

Hair Cells

40.3K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
40.3K
Anatomy of the Ear01:16

Anatomy of the Ear

8.4K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
8.4K

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相关实验视频

Updated: Jun 30, 2025

Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

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在芯片上的电声响应性状.

Yangnan Hu1,2, Jiayue Xing1, Hui Zhang1

  • 1State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.

Advanced materials (Deerfield Beach, Fla.)
|March 15, 2024
PubMed
概括
此摘要是机器生成的。

一个新的芯片上的囊平台使用导电性水凝和电声刺激 (EAS) 来生长有机体. 该系统可用于对内耳疾病和聋的药物进行高通量选.

关键词:
耳器官有机体 耳器官有机体导电性水凝是一种导电性水凝.电声刺激是一种电声刺激.微流体学 在微流体学方面器官在芯片上的器官

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Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays
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Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays

Published on: October 19, 2016

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Investigating Outer Hair Cell Motility with a Combination of External Alternating Electrical Field Stimulation and High-speed Image Analysis
09:35

Investigating Outer Hair Cell Motility with a Combination of External Alternating Electrical Field Stimulation and High-speed Image Analysis

Published on: July 18, 2011

13.5K

相关实验视频

Last Updated: Jun 30, 2025

Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

14.6K
Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays
07:51

Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays

Published on: October 19, 2016

9.9K
Investigating Outer Hair Cell Motility with a Combination of External Alternating Electrical Field Stimulation and High-speed Image Analysis
09:35

Investigating Outer Hair Cell Motility with a Combination of External Alternating Electrical Field Stimulation and High-speed Image Analysis

Published on: July 18, 2011

13.5K

科学领域:

  • 生物医学工程 生物医学工程
  • 再生医学是一种再生医学.
  • 神经科学是一个神经科学.

背景情况:

  • 器官芯片技术为研究和药物开发提供了器官生理学的先进模拟.
  • 构建功能性带芯片模型仍然是一个重大挑战.
  • 现有的模型缺乏复杂性,无法完全复制内耳功能.

研究的目的:

  • 开发一种新型的耳在芯片上的平台,集成耳器官和导电性水凝.
  • 利用耳植入物电声刺激 (EAS) 来增强器官发育.
  • 建立一个高通量系统来评估内耳疾病的药物.

主要方法:

  • 在导电性水凝生物混合系统中整合内耳前代细胞.
  • 使用EAS培养原生细胞成为自我塑造的耳器官.
  • 将有机物纳入一个带有度梯度发生器的微流体脏在芯片上的装置.

主要成果:

  • 导电性水凝支持原生细胞的增殖和可活性耳器官的形成.
  • 在发育的有机体内观察到结构成熟的毛细胞.
  • 该平台成功展示了与内耳疾病相关的药物的动态,高通量评估.

结论:

  • 开发的芯片上的叶平台显示了有机种植的巨大潜力.
  • 这种系统对在聋症研究中高通量药物查具有前景.
  • 生物杂交方法促进了功能性内耳模型的开发.