在肝细胞癌的转化疗法过渡的预测因素使用阿特佐利祖马布加贝瓦西祖马布
Tatsuya Kikuchi1, Yasuto Takeuchi1,2, Kazuhiro Nouso3
1Department of Gastroenterology and Hepatology, Okayama University Hospital, Okayama City, Japan.
概括
巴塞罗那诊所肝癌 (BCLC) 阶段A或B预测,在治疗阿特佐利祖马布和贝瓦西祖马布后,对不可切除的肝细胞癌 (HCC) 进行成功的转化疗法. 较少的病变和较早的治疗改善了无癌症的结果.
科学领域:
- 肝胆瘤学 肝胆瘤学
- 胃肠道医疗瘤学
- 翻译癌症研究 翻译癌症研究
背景情况:
- 无法切除的肝细胞癌 (HCC) 提出了治疗挑战.
- 与阿特佐利祖马布和贝瓦齐祖马布的联合治疗对先进的HCC有希望.
- 确定转化疗法成功的因素对于改善患者的治疗结果至关重要.
研究的目的:
- 为了确定成功转换疗法的预测因素,HCC患者接受了阿特佐利祖马布和贝瓦西祖马布治疗.
- 为了确定与实现癌症免费状态转化后治疗相关的临床因素.
主要方法:
- 对接受一线阿特佐利祖马布加贝瓦齐祖马布治疗的188名HCC患者的回顾性分析.
- 排除仅用化疗实现完全反应的患者.
- 确定与转化疗法和无癌症状态相关的临床因素.
主要成果:
- 8.0%的患者 (15/188) 接受了转化疗法.
- 巴塞罗那诊所肝癌 (BCLC) 阶段A或B是转化疗法的重要预测因素 (OR 3.7;p=0.04).
- 无癌症状态与较少的肝脏内病变和转化疗法间隔较短有关.
结论:
- BCLC 阶段是用阿特佐利祖马布和贝瓦西祖马布治疗的 HCC 转换疗法成功的主要预测因素.
- 实现无癌症状态与较低的瘤负担和及时过渡到转化疗法有关.
- 这些发现有助于选择HCC患者接受转化疗法,以最大限度地提高治愈潜力.
关键词:
巴塞罗那诊所肝癌阶段这是一种α-fetoprotein.它们是Atezolizumab.这是bevacizumab的治疗方法.没有癌症的无癌症.儿童 - 皮厄斯评分转换疗法的转换疗法.肝细胞癌是肝细胞癌.现实世界的实践实践.瘤的反应反应.更多相关视频
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