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Updated: Jun 30, 2025

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生成一个人性化的mAce2和条件的haCE2小鼠模型,允许SARS-COV-2感染

I-Wen Song1, Megan Washington1, Carolina Leynes1

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.

Mammalian genome : official journal of the International Mammalian Genome Society
|March 15, 2024
PubMed
概括

开发了两种新的小鼠模型来研究严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2). 罗莎26hACE2;CMV-Cre模型有效地模仿了人类的SARS-CoV-2感染症状,有助于研究.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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